Scientific discoveries, technological breakthroughs and research.
A 2 November study found a shift in prolactin-receptor variants in immune cells from people with lupus. An experimental oligonucleotide reduced harmful immune activity and kidney damage in mice; no treatment benefit in patients has been demonstrated.
Chinese researchers developed a drone flight-planning model that adjusts inspection distance and height. NSGA-III achieved full coverage in modeled comparisons, but real-world performance remains unverified.
A new Scientific Reports study models the effects of climate and population change since 1975 on the number of people exposed to flooding during Cyclone Idai in 2019. The headline 84% is not a share of deaths or damage.
US researchers compared blood RNA profiles in heat-tolerant and heat-sensitive Brangus cattle. The more resilient group showed fewer gene-expression changes between hot and cool conditions; MFAP5 and NOVA1 are research candidates, not validated breeding tests.
A November 2 study combines blood and transplant-biopsy data to describe immune cells clustering near CXCL12-producing fibroblasts in chronic antibody-mediated kidney rejection. The finding is mechanistic, not a validated treatment.
Researchers analysed 247,107 UK Biobank participants and identified four blood-metabolite obesity subtypes. Two were associated with higher rates of sarcopenia and intervertebral disc disease; causation has not been established.
In a 156-patient phase 2 trial, starting dual HER2-targeted therapy earlier alongside liposomal doxorubicin was associated with a higher pathological complete response rate. Long-term survival benefit is not established.
